Prof. Edus Houston Warren, MD, Ph.D

Prof. Edus Houston Warren is a Professor in Immunology Clinical Research Division, Fred Hutch, Program Head Global Oncology Program, Fred Hutch and the Professor

Vaccine and Infectious Disease Division, Fred Hutch.

He is a physician-scientist who contributed to the development of adoptive T-cell therapy, which harnesses the body’s immune system to block cancers. He currently leads the Global Oncology Program at the Fred Hutchinson Cancer Center, whose mission is to do research that will improve the prevention and treatment of cancers in low- and middle-income countries. The Hutch Global Oncology Program is physically based in Kampala, Uganda at the UCI – Fred Hutch Cancer Centre, on the campus of the Uganda Cancer Institute.

Career Highlights:

• As an oncologist, Dr. Warren specializes in the treatment of patients with blood cancers such as leukemia, lymphoma, and multiple myeloma.
• He has considerable experience as an investigator on clinical trials of novel agents for the treatment of blood cancers and served as the Principal Investigator on a Phase I clinical trial of T cell immunotherapy for patients with relapse of acute leukemia or high-grade myelodysplasia after allogeneic hematopoietic cell transplantation.
• The overall focus of Dr. Warren’s laboratory is cancer immunology. His group studies the mechanisms and molecules that mediate tumor regression after treatment with immunotherapy such as immune-checkpoint inhibition and adoptive T-cell therapy.
• His lab has extensive experience with the characterization and manipulation of human T and B lymphocytes, identification of antigens recognized by T and B lymphocytes, and assessment of adoptive cellular therapy in preclinical models.
• With two Fred Hutch colleagues, Dr. Warren co-developed an innovative next-generation DNA sequencing approach that enables comprehensive analysis of T- and B-lymphocyte repertoires.
• Warren’s laboratory also has a strong research focus on lymphomas that affect children and adults in sub-Saharan Africa, particularly Burkitt lymphoma and diffuse large B-cell lymphoma.

Education:

• Fellow, Medical Oncology; University of Washington 1993-1996
• Intern and Resident, Internal Medicine; Massachusetts General Hospital; 1991-1993
• MD, Harvard Medical School, 1991
• PhD, Neurobiology; Harvard University, 1988
• AB, Applied Mathematics; Harvard College, 1982